Adriana San-Miguel

Assistant Professor
Department of Chemical and Biomolecular Engineering

Ph.D. (2011), Georgia Institute of Technology

San-Miguel received a B.S. in chemical engineering from the Monterrey Institute of Technology and Higher Education (ITESM) in 2005. After spending two years working in industry, she moved to the United States to pursue a graduate degree. She obtained a Ph.D. in chemical engineering from the Georgia Institute of Technology in 2011. As a member of the Behrens Research Group, she worked on the development of microcapsules and stimulus-responsive systems. Motivated by a growing interest in biology, she turned her research efforts to engineering solutions for biological studies. Prior to joining NC State, she worked as a postdoctoral fellow in Professor Hang Lu's group at Georgia Tech. She also held an appointment as a research fellow with Professor Marc Vidal at the Center for Cancer Systems Biology (Dana-Farber Cancer Institute and Harvard Medical School). In 2013, she was awarded an NIH K99 Pathway to Independence Award from the National Institute of Aging to study the mechanisms regulating synaptic plasticity and aging in the nematode C. elegans.

Currently, she works with the well-studied nematode C. elegans, a simple multicellular model organism useful for studies ranging from development to neuroscience and aging. Her expertise is focused on developing experimental platforms that enable high-throughput automated extraction of biological data, mainly from images of subcellular biological features in a live organism. These platforms are made possible by combining microfluidics, automation, custom designed external hardware and image processing. In this way, it is possible to obtain large multivariate data sets in an unbiased manner, enabling experimentation and understanding of biological phenomena from a systems perspective.

Research Interests

Systems biology, high-throughput biological data acquisition, microfluidics, unsupervised image analysis, neuroscience and aging

Selected Publications

  • C. Maeder, A. San-Miguel, E. Wu, H. Lu, K. Shen. In vivo neuron-wide microscopy reveals differential regulation of synaptic vesicle precursor trafficking. Traffic. 2014, 15(3), 273-91.